Indy Car rookie Alexander Rossi stunned the field by having just enough gas to hang on for his first win. Truex led for 392 of the 400 laps in wrapping up his first Sprint Cup win of the season.
The only time he gave up the lead was when he pitted and others stayed on the track.
Kevin Harvick finished second and Jimmie Johnson was third.
Denny Hamlin was fourth and Brad Keselowski finished fifth.
Truex has had several unfortunate mishaps this season preventing him from getting his fourth career win.
But there was no denying the 35-year-old from capturing his first Coca-Cola 600 win.
Truex had never finished better than fifth place at CMS.___ p.m.Defending Coca-Cola 600 champion Carl Edwards was penalized twice for speeding on pit row, dropping him from third to 21st and a lap down.The latest on motorsport's busiest day, with Formula One's Monaco Grand Prix followed by the Indianapolis 500 and NASCAR's Coca-Cola 600 (all times local):___ p.m.Eastern The biggest day in global motorsports turned out to be one full of firsts.At the Monaco Grand Prix, defending Formula One champion Lewis Hamilton picked up his first win of the season — and first win in the past eight races overall, dating to last year.Then came the 100th running of the Indianapolis 500, where top names like Ryan Hunter-Reay, Tony Kanaan and Helio Castroneves were high on the leaderboard. Truex also set a record by leading for all but 12 of the 600 miles in NASCAR's longest race.___ p.m. has won the Coca-Cola 600, dominating the long NASCAR race in a record-setting fashion.